Table 1 Binding energies of PTX with key gene target proteins.

From: Unraveling the molecular mechanisms of paclitaxel in high-grade serous ovarian cancer through network pharmacology

Target protein

Drug

PTX (kcal/mol)

Aurora kinase A (AURKA)

− 7.7

Polycomb group ring finger protein 7 (CBX7)

− 6.8

Cyclin A2 (CCNA2)

− 8.4

Heat shock protein 90α (HSP90AA1)

− 6.3

Tubulin beta-3 chain (TUBB3)

− 7.4

Back to article page