Table 1 Demographic and clinical characteristics of the 89 patients enrolled with mild CAP or SCAP.

From: Prospective multicenter study identifying prognostic biomarkers and microbial profiles in severe CAP using BALF, blood mNGS, and PBMC transcriptomics

Characteristics

Mild CAP(n = 14)

SCAP (survivor) (n = 43)

SCAP (death) (n = 32)

SCAP (survivor) vs Mild CAP

SCAP (death) vs Mild CAP

SCAP (death) vs SCAP (survivor)

Age (n = 14/43/32)

62.29 ± 14.90

58.56 ± 17.57

69.00 ± 15.64

0.4785

0.1812

0.0095**

Sex (n = 14/43/32)

 Male

6(42.86%)

37(86.05%)

24(75%)

0.0011**

0.0352*

0.2246

 Female

8(57.14%)

6(13.95%)

8(25%)

BMI(n = 13/38/27)

24.39 ± 4.923

23.29 ± 2.957

22.82 ± 5.041

0.3388

0.3585

0.6374

Previous history

 Smoking (n = 13/42/32)

6(46.15%)

16(37.21%)

10(31.25%)

0.6043

0.3438

0.5411

 Drinking (n = 13/42/32)

2(15.38%)

8(18.6%)

3(9.38%)

0.7648

0.5610

0.2466

 Operation history (n = 13/42/29)

4(30.77%)

13(30.95%)

9(31.03%)

0.9900

0.9863

0.9941

 Allergic history (n = 13/42/32)

2(15.38%)

4(9.52%)

9(28.13%)

0.5536

0.3674

0.0372*

 Comorbidities (n = 13/42/32)

8(61.54%)

36(85.71%)

30(93.75%)

0.0569

0.0069**

0.2701

 Cancer (n = 13/42/32)

1(7.69%)

7(16.67%)

4(12.5%)

0.4225

0.6418

0.6177

 Chronic lung disease(n = 13/42/32)

5(38.46%)

11(26.19%)

8(25%)

0.3946

0.3665

0.9075

 Diabetes(n = 13/42/31)

0(0%)

7(16.67%)

7(22.58%)

0.1151

0.0617

0.5258

 Hypertension(n = 13/42/31)

3(23.08%)

13(30.95%)

15(48.39%)

0.5848

0.1192

0.1300

 Cardiac insufficiency(n = 13/42/31)

2(15.38%)

5(11.9%)

3(9.68%)

0.7422

0.5863

0.3011

 Renal insufficiency (n = 13/42/31)

2(15.38%)

5(11.9%)

1(3.23%)

0.7422

0.1443

0.1820

 Cerebrovascular disease(n = 13/42/32)

1(7.69%)

3(7.14%)

10(31.25%)

0.6843

0.0956

0.0022**

 Neurological diseases (dementia, Parkinson’s, etc.) (n = 13/42/31)

0(0%)

2(4.76%)

4(12.9%)

0.4228

0.1743

0.2106

 Mental disease (n = 13/42/30)

0(0%)

3(7.14%)

2(6.67%)

0.3217

0.3486

0.9080

Respiratory therapy (n = 14/41/30)

 Nasal tube oxygen

8(57.14%)

15(36.59%)

15(50%)

0.1782

0.6586

0.2583

 Mask oxygen inhalation

0(0%)

2(4.88%)

1(3.33%)

0.3999

0.4895

0.7493

 Nasal high flow humidified oxygen therapy (HFNC)

0(0%)

9(21.95%)

3(10%)

0.0553

0.2203

0.1844

 Non-invasive mechanical ventilation (NIPPV)

0(0%)

1(2.44%)

1(3.33%)

0.5554

0.4895

0.8220

 Invasive mechanical ventilation (IPP)

0(0%)

15(36.59%)

10(33.33%)

0.0080**

0.0140*

0.7769

  1. * P < 0.05, ** P < 0.01, *** P < 0.001.