Table 3 Comparison of pathogen detection performance between DNA + RNA mNGS in BALF and blood samples versus CMTs among mild CAP, SCAP (survivor), SCAP (death) patients.

From: Prospective multicenter study identifying prognostic biomarkers and microbial profiles in severe CAP using BALF, blood mNGS, and PBMC transcriptomics

Patient type

Blood + BALF mNGS vs CMTs

Blood mNGS vs CMTs

BALF mNGS vs CMTs

Blood + BALF mNGS vs BALF mNGS

Blood + BALF mNGS vs Blood mNGS

BALF mNGS vs Blood mNGS

Detection rate of Bacteria

 Mild CAP(n = 13)

61.54%vs 23.08% (P = 0.0472)

38.46% vs 23.08% (P = 0.3954)

53.85% vs 23.08% (P = 0.2262)

61.54% vs 53.85% (P = 0.6914)

61.54% vs 38.46% (P = 0.2393)

53.85% vs 38.46% (P = 0.4314)

 SCAP (survivor) (n = 40)

85% vs 42.5% ( P < 0.0001)

47.5% vs 42.5% (P = 0.6531)

82.5% vs 42.5% ( P < 0.0001)

85% vs 82.5% (P = 0.3031)

85% vs 47.5% (P = 0.0004)

82.5% vs 47.5% (P = 0.001)

 SCAP (death) (n = 24)

62.5% vs 62.5% (P = 1.000)

33.33% vs 62.5% (P = 0.0431)

58.33% vs 62.5% (P = 0.7679)

62.5% vs 58.33% (P = 0.7679)

62.5% vs 33.33% (P = 0.0431)

58.33% vs 33.33% (P = 0.0822)

Detection rate of Fungi

 Mild CAP(n = 13)

15.38% vs 7.69% (P = 0.5393)

7.69% vs 7.69% (P = 1.000)

15.38% vs 7.69% (P = 0.5393)

15.38% vs 15.38% (P = 1.000)

15.38% vs 7.69% (P = 0.5393)

15.38% vs 7.69% (P = 0.5393)

 SCAP (survivor) (n = 40)

42.5% vs 20% (P = 0.0299)

7.5% vs 20% (P = 0.1045)

42.5% vs 20% (P = 0.0299)

42.5% vs 42.5% (P = 1.000)

42.5% vs 7.5% (P = 0.0003)

42.5% vs 7.5% (P = 0.0003)

 SCAP (death) (n = 24)

50% vs 29.17% (P = 0.1400)

8.33% vs 29.17% (P = 0.0645)

50% vs 29.17% (P = 0.1400)

50% vs 50% (P = 1.000)

50% vs 8.33% (P = 0.0015)

50% vs 8.33% (P = 0.0015)

Detection rate of DNA virus

 Mild CAP(n = 13)

–

–

–

76.92% vs 69.23% (P = 0.6584)

76.92% vs 61.54% (P = 0.5683)

61.54% vs 76.92% (P = 0.5683)

 SCAP (survivor) (n = 40)

–

–

–

87.5% vs 67.5% (P = 0.0322)

87.5% vs 80% (P = 0.2039)

67.5% vs 87.5% (P = 0.0322)

 SCAP (death) (n = 24)

–

–

–

95.83% 87.5% (P = 0.2963)

95.83% vs 91.67% (P = 0.6366)

87.5% vs 95.83% (P = 0.2963)

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