Table 1 Characterization of Mitoxantrone thermosensitive liposomes.
Batch | Lipid composition (molar ratio) | Particle size (nm) | Zeta potential (mV) | pH | Osmotic pressure (mOsmol/Kg) | EE (%) | Drug content (mg/mL) |
|---|---|---|---|---|---|---|---|
1 | DPPC: MSPC: DSPE-mPEG2000 (90:10:4) | 98.61 | −34.52 | 6.52 | 309 | 98.66 | 1.10 |
2 | DPPC: MSPC: DSPE-mPEG2000 (90:10:4) | 101.60 | −32.35 | 6.51 | 307 | 98.34 | 1.07 |
3 | DPPC: MSPC: DSPE-mPEG2000 (90:10:4) | 100.10 | −33.66 | 6.55 | 312 | 98.22 | 1.03 |
Mean | DPPC: MSPC: DSPE-mPEG2000 (90:10:4) | 100.10 ± 1.50 | −33.51 ± 1.09 | 6.53 ± 0.02 | 309 ± 3 | 98.41 ± 0.23 | 1.07 ± 0.04 |
