Table 3 Mediation analysis of the mediation effect of atrial fibrillation in abnormal CMR induced by the four domains.
From: Impact of gene-environment interactions on atrial fibrillation and cardiac structure
Exposure | Outcome | Total effect | Mediation effect | ||
|---|---|---|---|---|---|
Effect size | P | Effect size | P | ||
Air pollution score | LA Minimum volume | 0.063 | 0.087 | 0.033 | 0.003** |
LAEF | – 0.09 | 0.001 *** | – 0.017 | 0.003** | |
Minimum volume of RA | – 0.096 | 0.071 | 0.68 | 0.004** | |
Ascending aorta minimum area | – 0.734 | 0.182 | 0.065 | 0.009** | |
Descending aorta minimum area | 0.108 | 0.581 | 0.033 | 0.005** | |
LV average myocardial wall thickness AHA 9 | – 0.002 | 0.402 | 0.001 | 0.005** | |
Noise pollution score | LA Minimum volume | 0.054 | 0.636 | 0.018 | 0.537 |
LAEF | – 0.039 | 0.586 | 0.009 | 0.54 | |
Minimum volume of RA | 0.061 | 0.68 | 0.012 | 0.538 | |
Ascending aorta minimum area | 0.333 | 0.777 | 0.035 | 0.542 | |
Descending aorta minimum area | – 0.306 | 0.508 | 0.018 | 0.535 | |
LV average myocardial wall thickness AHA 9 | – 0.002 | 0.781 | 0 | 0.526 | |
Greenspace score | LA Minimum volume | – 0.05 | 0.122 | 0.025 | 0.002** |
LAEF | – 0.016 | 0.409 | – 0.013 | 0.002** | |
Minimum volume of RA | – 0.305 | 0.001 *** | 0.016 | 0.003** | |
Ascending aorta minimum area | 0.058 | 0.881 | 0.048 | 0.009** | |
Descending aorta minimum area | 0.499 | 0.001** | 0.025 | 0.007** | |
LV average myocardial wall thickness AHA 9 | 0.003 | 0.125 | 0 | 0.004** | |
Water score | LA Minimum volume | – 0.04 | 0.6 | 0.017 | 0.427 |
LAEF | – 0.087 | 0.065 | – 0.008 | 0.428 | |
Minimum volume of RA | – 0.079 | 0.351 | 0.011 | 0.424 | |
Ascending aorta minimum area | 1.49 | 0.075 | 0.032 | 0.447 | |
Descending aorta minimum area | 0.579 | 0.146 | 0.016 | 0.45 | |
LV average myocardial wall thickness AHA 9 | 0.001 | 0.834 | 0 | 0.449 | |
