Fig. 6 | Scientific Reports

Fig. 6

From: A bioinformatics-driven approach to identify biomarkers and elucidate the pathogenesis of type 2 diabetes concurrent with pulmonary tuberculosis

Fig. 6

Highly correlated hub gene-miRNA network involved in PTB + T2DM. Utilizing the MEgreenyellow module genes extracted via WGCNA (refer to Fig. 2), MEGENA was deployed to delve deeper into pivotal genes implicated in PTB + T2DM. This analysis unveiled LINC00278, MMP9, MMP8, C1QA, CD248, and FN1 as genes strongly correlated with PTB + T2DM. The five key genes correlated with miRNAs. C1QA correlated with hsa-miR-363-5p, hsa-miR-671-5p, and hsa-miR-25-5p; CD248 correlated with COL1 A2, COL1 A1, and COL4 A1; MMP8 correlated with hsa-miR-539-5p, MMP9, and CEACAM8; and MMP9 correlated with FN1, MMP8, hsa-miR-29b-3p, hsa-miR-942-3p, hsa-miR-302-5p, and hsa-miR-133a-5p.

Back to article page