Fig. 7 | Scientific Reports

Fig. 7

From: A bioinformatics-driven approach to identify biomarkers and elucidate the pathogenesis of type 2 diabetes concurrent with pulmonary tuberculosis

Fig. 7

Sensitivity analysis of seven drugs in relation to C1QA expression in PTB + T2DM. Based on the expression data of C1QA in the PTB + T2DM group from GSE181143, samples were divided into high and low expression groups by sorting the expression data from highest to lowest and selecting the top 25% and bottom 25% intervals, respectively. The pRRophetic algorithm was then employed to assess disparities in drug sensitivity between these two expression groups of C1QA. Among which seven drugs, namely ERK_440_1713, JAK_8517_1739, Palbociclib_1054, PLX.4720_1036, Savolitinib_1936, Selumetinib_1736, and VX.11e_2096, were chosen to predict drug sensitivity on the basis of high or low C1QA expression levels in patients with PTB + T2DM.

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