Fig. 4 | Scientific Reports

Fig. 4

From: Insights into the special physiology of Mortierella alpina cultured by agar supported solid state fermentation in enhancing arachidonic acid enriched lipid production

Fig. 4

An overview of transcriptional differences in lipid metabolism pathway among SH, AH and VH. In M. alpina M0223 cultured with glucose as carbon source, pyruvate produced from glucose via the EMP pathway undergoes the TCA cycle in the mitochondria to synthesize citrate. When the produced citrate overflows from the TCA cycle, the carbon flux shifts into fatty acid synthesis by fatty acid synthetase (FAS) in the cytoplasm. The synthesized fatty acids subsequently form triglycerides via the Kennedy pathway or enter glycerophospholipid metabolism and are desaturated or elongated in the form of phosphatidylcholine or acyl CoA via the fatty acid desaturase/elongase system. Besides, the synthesized fatty acids can be degraded by mitochondrial and peroxisomal fatty acid β-oxidation (f). Heatmap of genes with significant differences among AH, SH and VH in EMP (a1), TCA (b), FAO (c), triacylglycerol biosynthesis (d1) and glycerophospholipid metabolism (e1). GSEA results of glycolysis (a2), triacylglycerol biosynthesis (d2) and glycerophospholipid metabolism (e2) between SH and VH.

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