Table 1 Demographic and APOE genotype/allele data in study participants.
From: Search for the elusive haplotype of the APOE polymorphism associated with Alzheimer’s disease
Total Sample (N = 14819) | AD Cases (N = 3280) | Controls (N = 11535) | P-value between cases and controls | |
|---|---|---|---|---|
Mean age ± SD | 72.7 ± 14.2 | 72.1 ± 9.8 | 72.9 ± 15.2 | 4.94E-04 |
Female, N (%) | 8142 (56.6) | 2000 (61.0) | 6141 (55.4) | 1.20E-08 |
White/Black/ Others (%) | 86.8/12.7/0.5 | 93.4/6.3/0.3 | 84.8/14.6/0.6 | 1.36E-36 |
APOE Genotype N (%) | 1.95E-238 | |||
2/2 | 88 (0.6) | 8(0.2) | 80 (0.7) | |
2/3 | 1557 (10.5) | 163(5.0) | 1394(12.1) | |
2/4 | 355 (2.4) | 88(2.7) | 267(2.3) | |
3/3 | 8254 (55.7) | 1280(39.0) | 6973(60.5) | |
3/4 | 3948 (26.6) | 1415(43.1) | 2531(21.9) | |
4/4 | 617 (4.2) | 326(10.0) | 290(2.5) | |
APOE Allele Frequency (%) | 7.08E-254 | |||
E2 | 7.1 | 4.1 | 7.9 | |
E3 | 74.2 | 63.1 | 77.5 | |
E4 | 18.7 | 32.8 | 14.6 |
