Fig. 1

Screening for DEGs. (a) Volcano plot of DEGs in TCGA-HCC. (b) Heatmap of DEGs in TCGA-HCC. The numerical range was from − 1 to 3, representing values related to gene expression levels. The legend on the right side showed that colors corresponded to expression densities, with red indicating high expression density and blue indicating low expression density. The black lines represented different quantiles, such as 0%, 25%, 50%, 75%, and 100%, and the data distribution was presented. (c) NETs-RGs scores between tumor and normal samples. (d) The survival probability of the two risk groups. Blue represents patients in low risk group and red represents patients in high risk group (p-value = 0.00049) LIHC = 374, control = 50, NETs-RGs = 87. (e) The hierarchical clustering analysis among all samples. (f) Determination of the soft thresholding power. The y-axis of the left panel represents the scale-free fit index and the y-axis of the right panel represents the mean connectivity. The x-axis represents power value. (g) Dendrogram of differentially expressed genes clustered. The colors represent the identified gene modules. (h) Correlations of gene modules with NETs-RGs scores.