Table 5 MiRNA signature: controls vs. High-Risk group (Gleason > 7).

From: Role of circulating MicroRNAs in prostate cancer diagnosis and risk stratification in the MCC Spain study

miRNA

TMM

cases*

TMM

controls*

log2(FC)

Fold change*

Odds ratio

(95% CI)**

P**

Odds ratio

(95% CI)***

P***

miR-150-5p

−0.148

0.316

−0.464

0.725

0.64 (0.39–1.04)

0.074

0.68 (0.40–1.17)

0.164

miR-199a-5p

−3.574

−4.267

0.693

1.617

1.31 (0.82–2.11)

0.255

1.29 (0.78–2.11)

0.321

miR-24-3p

2.317

1.805

0.512

1.426

2.93 (1.43–5.98)

0.003

2.73 (1.29–5.77)

0.009

  1. Notes:.
  2. • TMM (Trimmed Mean of M-values): Method used for miRNA expression normalization.
  3. • Fold change (FC): Ratio of expression between cases and controls (FC > 1 indicates overexpression; FC < 1 indicates underexpression). log₂(FC) is the base-2 logarithmic transformation of FC.
  4. • Crude (unadjusted) vs. Adjusted (** and ***): The unadjusted model does not control for any confounders; the second model is adjusted for all miRNAs included in the final set; the third model also adjusts for age, BMI, educational level, socioeconomic status, and smoking.
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