Table 2 Diagnostic accuracy of 99mTc-FAPI SPECT/CT and 18F-FDG PET/CT.
Index | TP | FP | TN | FN | Sensitivity(%) | Specificity(%) | Accuracy(%) | PPV(%) | NPV(%) |
|---|---|---|---|---|---|---|---|---|---|
Primary tumor | |||||||||
18F-FDG | 33 | 0 | 0 | 0 | 100 | …† | 100 | 100 | …† |
99mTc-FAPI | 33 | 0 | 0 | 0 | 100 | …† | 100 | 100 | …† |
LN metastases | |||||||||
18F-FDG | 142 | 3 | 18 | 38 | 79(142/180) | 86(18/21) | 80(160/201) | 98(142/145) | 32(18/56) |
99mTc-FAPI | 127 | 0 | 21 | 53 | 71(127/180) | 100(21/21) | 74(148/201) | 100(127/127) | 28(21/74) |
χ2 | 3.309 | 3.231 | 1.999 | 2.657 | 0.215 | ||||
P value | 0.069 | 0.232 | 0.157 | 0.251 | 0.643 | ||||
Peritonea metastases | |||||||||
18F-FDG | 3 | 0 | 33 | 12 | 20(3/15) | 100(33/33) | 75(36/48) | 100(3/3) | 69(33/48) |
99mTc-FAPI | 15 | 0 | 33 | 0 | 100(15/15) | 100(33/33) | 100(48/48) | 100(15/15) | 100(33/33) |
χ2 | 20.000 | …† | 13.714 | …† | 10.400 | ||||
P value | <0.001 | …† | <0.001 | …† | 0.001 | ||||
Liver metastases | |||||||||
18F-FDG | 10 | 0 | 14 | 10 | 50(10/20) | 100(14/14) | 71(24/34) | 100(10/10) | 58(14/24) |
99mTc-FAPI | 17 | 0 | 14 | 3 | 85(17/20) | 100(14/14) | 91(31/34) | 100(17/17) | 82(14/17) |
χ2 | 5.584 | …† | 4.660 | …† | 2.651 | ||||
P value | 0.041 | …† | 0.062 | …† | 0.173 | ||||
Metastases in other sites | |||||||||
18F-FDG | 12 | 1 | 10 | 5 | 71(12/17) | 91(10/11) | 79(22/28) | 92(12/13) | 67(10/15) |
99mTc-FAPI | 17 | 0 | 11 | 0 | 100(17/17) | 100(11/11) | 100(28/28) | 100(17/17) | 100(11/11) |
χ2 | 5.862 | 1.048 | 6.720 | 1.353 | 4.540 | ||||
P value | 0.044 | 1.000 | 0.023 | 0.433 | 0.053 |
