Fig. 4 | Scientific Reports

Fig. 4

From: Highly specific Immunoproteasome inhibitor M3258 induces proteotoxic stress and apoptosis in KMT2A::AFF1 driven acute lymphoblastic leukemia

Fig. 4

Treatment with PIs induces proteotoxic stress. (a) Effect of PIs on gene expression in SEM cells. Cells treated with 20 nM Btz, 1 µM M3258, and 0.8 µM ONX-0914 and harvested for RNA isolation 1 h before detectable increase in the caspase-like activity. (b) Analysis of RNA sequencing data from (a) by the Ingenuity Pathway Analysis (IPA). BAG2 SP, BAG2 signaling pathway. (c) IPA of RNA sequencing data of Btz-treated primary ALL cells from37. (d) Gene-set enrichment analysis (GSEA) of data from (a). (e) Analysis of published proteomic data from Btz-treated SEM cells37.

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