Table 2 List of metabolites that differed significantly in lung, heart, stomach, serum, spleen, intestines, liver and kidney samples from mice after SN-38 treatment.

From: Comprehensive metabolomics study identifies SN-38 organ specific toxicity in mice

Metabolite	HMDB ID	Lung			Heart			Stomach			Serum			Spleen			Intestine			Liver			Kidney
Metabolite	HMDB ID	VIP	p-value	Trend	VIP	p-value	Trend	VIP	p-value	Trend	VIP	p-value	Trend	VIP	p-value	Trend	VIP	p-value	Trend	VIP	p-value	Trend	VIP	p-value	Trend
L-Alanine	HMDB0000161	1.43185	0	↓	1.5608	0.003	↓	1.15808	0.023	↑				1.68741	0	↓	1.66198	0.002	↓				1.27615	0	↓
Ethanolamine	HMDB0000149	1.42849	0	↓	1.26673	0	↓	1.4888	0.007	↓	1.33237	0.003	↓	1.18623	0	↓
Glycine	HMDB0000123				1.40574	0	↓				2.03319	0	↓	1.62385	0	↓	1.41217	0.002	↓				1.3884	0	↓
Uracil	HMDB0000300	1.25803	0	↓	1.52355	0.001	↓							1.1417	0	↓	1.4811	0	↓	1.43853	0.001	↑
Serine	HMDB0062263	1.00729	0	↓	1.32922	0	↓	1.80309	0.001	↑	1.39477	0	↓	1.44171	0	↓	1.48091	0.005	↓
L-Threonine	HMDB0000167	1.16436	0	↓				1.28401	0.022	↑	1.6348	0	↓	1.51569	0	↓	1.49606	0.004	↓
L-5-Oxoproline	HMDB0000267	1.21667	0	↓	1.6697	0	↑							1.44595	0	↓	1.36197	0.008	↓				1.24731	0	↓
L-Aspartic acid	HMDB0000191	1.59829	0	↓				2.03692	0.001	↑				1.667	0	↓	1.1527	0.012	↓
L-Hydroxyproline	HMDB0000725	1.42872	0	↓
Taurine	HMDB0000251	1.64232	0	↓							1.54467	0.043	↓	1.56647	0.001	↓
Erythritol	HMDB0002994	1.06689	0.001	↓
Myristic acid	HMDB0000806	1.12475	0	↓										1.29796	0	↓	1.01626	0.002	↓				1.2056	0.002	↓
Myo-Inositol	HMDB0000211	1.04457	0	↓																1.03526	0.001	↑
Lactic Acid	HMDB0000190	1.50075	0	↓				2.48085	0	↓	1.28865	0.027	↓	1.82329	0	↓	1.49016	0.009	↓				1.81304	0	↓
Glyceric acid	HMDB0000139	1.25863	0	↓																			1.06429	0.012	↓
Malic acid	HMDB0000744	2.02242	0	↓	2.29639	0	↓				1.99384	0	↓	1.65963	0	↓	1.6327	0.001	↓				1.58496	0.001	↓
Phosphorylethanolamine	HMDB0000224	2.03988	0	↓	1.20574	0.004	↓							2.13797	0.001	↓	2.0118	0	↓				2.50558	0	↓
L-Lysine	HMDB0000182	1.5953	0	↓							1.22089	0.016	↓	1.84087	0	↓	1.59551	0.024	↓	1.0835	0	↓	1.81673	0	↓
L-Tyrosine	HMDB0000158	1.12706	0	↓							2.05449	0	↓	1.58114	0	↓	1.52078	0.004	↓	1.12152	0	↓	1.06791	0.004	↓
11-Octadecenoic acid	HMDB0003231	1.19638	0	↓
Arachidic acid	HMDB0002212	1.0138	0	↓													1.01931	0.002	↓				1.0305	0.047	↓
MG(0:0/18:1(9Z)/0:0)	HMDB0011537	1.15517	0.04	↓
MG(0:0/18:0/0:0)	HMDB0011535	1.13729	0	↓																			1.43048	0	↓
L-Valine	HMDB0000883							1.55952	0.004	↑	1.07133	0.034	↓	1.59536	0	↓	1.69261	0.002	↓
L-Proline	HMDB0000162							2.03295	0	↑	1.25163	0.001	↓	1.69751	0	↓
Pipecolic acid	HMDB0000070							1.63311	0.002	↑
L-Glutamic acid	HMDB0000148				1.63346	0.004	↓	1.44133	0.009	↑	1.69197	0	↓	1.52771	0	↓				1.00108	0.003	↓	1.12096	0.003	↓
Petroselinic acid	HMDB0002080							1.15756	0.023	↓							1.4087	0	↓	1.15674	0.006	↑
Succinic acid	HMDB0000254							2.12961	0.001	↓	1.81357	0.001	↓										2.12777	0	↓
Phenylalanine	HMDB0000159													1.38987	0.001	↓	1.55429	0.005	↓				1.08807	0.002	↓
L-Isoleucine	HMDB0000172													1.53587	0	↓	1.74659	0.002	↓				1.11152	0.001	↓
L-Methionine	HMDB0000696				1.70484	0	↓				1.3893	0.001	↓	1.45341	0	↓	1.59407	0.004	↓
L-Ornithine	HMDB0000214										1.56836	0.004	↓										1.56418	0	↓
L-Tryptophan	HMDB0000929										1.55396	0.001	↓	2.11505	0.001	↓
Cholesterol	HMDB0000067										1.4858	0.004	↓				1.2265	0	↓	1.27767	0.001	↑
5-Aminovaleric acid	HMDB0003355										1.67392	0.009	↓
Dodecanoic acid	HMDB0000638													1.12705	0.043	↓
Stearic acid	HMDB0000827													1.18693	0.001	↓	1.25653	0	↓	1.23325	0.001	↑
Urea	HMDB0000294													1.44196	0.001	↓
L-Arabitol	HMDB0001851													1.43152	0.005	↓							1.28594	0.006	↓
L-Leucine	HMDB0000687													1.53919	0	↓	1.67731	0.003	↓				1.02754	0.003	↓
D-Mannitol	HMDB0000765																			1.13177	0.001	↑	1.25664	0.001	↓
Asparagine	HMDB0000168													1.94572	0	↓							1.4482	0.002	↓
D-Glucose	HMDB0000122										2.3219	0	↓
Gluconic acid	HMDB0000625																			1.05046	0.004	↓
Oxalic acid	HMDB0002329																			1.21659	0.001	↑
Ribitol	HMDB0000508																			1.0579	0.009	↓
Hexadecane	HMDB0033792																			1.58377	0	↑
Docosahexaenoic acid	HMDB0002183													1.41852	0.006	↓	1.01199	0.004	↓	1.32795	0.001	↑	1.33549	0.001	↓
2-Aminooctanoic acid	HMDB0000991																						1.89931	0	↓
D-Arabitol	HMDB0000568																						1.2075	0.003	↓
2-Phenylbutyric acid	HMDB00329																						1.12875	0.012	↓
Glycerol	HMDB0000131	1.30896	0	↓							1.1409	0.001	↓	1.30749	0	↓	1.08352	0	↓				1.46021	0	↓
Niacinamide	HMDB0001406	1.00698	0	↓
Hypoxanthine	HMDB0000157				1.17903	0.005	↓
Adenine	HMDB0000034				1.15503	0.033	↑
MG(16:0/0:0/0:0)	HMDB0011564				1.01955	0.005	↓																1.49898	0	↓
Inosine	HMDB0000195				1.32579	0.002	↑
Adenosine	HMDB0000050				1.91973	0.001	↑
Citric acid	HMDB0000094										1.64524	0.001	↓
Beta-Alanine	HMDB0000056													1.6621	0	↓
4-Hydroxybenzyl alcohol	HMDB0011724													1.26064	0.003	↓
Palmitic acid	HMDB0000220													1.19475	0.001	↓				1.0434	0	↑
Ribothymidine	HMDB0000884													1.2569	0.003	↓
Uridine	HMDB0000296													1.32668	0.005	↓
N-Dodecane	HMDB0031444																1.22568	0.038	↓	1.42558	0.001	↑
Arachidonic acid	HMDB0001043																1.12277	0.005	↓	1.55127	0	↑
L-Galactose	HMDB0033704																			1.33935	0.012	↓
muco-Inositol	HMDB0062138																						1.54508	0.009	↓

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Table 2 List of metabolites that differed significantly in lung, heart, stomach, serum, spleen, intestines, liver and kidney samples from mice after SN-38 treatment.

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