Fig. 1
From: Chronic rejection models for vascularized composite tissue allotransplantation
Graft survival curves after vascularized composite tissue allotransplantation (VCA) in the syngeneic, acute, chronic KO, and chronic BM12 rejection models. C57BL/6 mice were used as donors and recipients in the syngeneic model, and BALC/c strain was used as a donor for the acute and chronic KO rejection models with different strains for recipients as C57BL/6 WT and C57BL/6 CD8 KO respectively. In the chronic BM12 model, B6(C)-H2-Ab1bm12 donors were transplanted to C57BL/6 CD8 KO recipients. VCA was performed at Day 0, and the gross finding was assessed every day. The survival of the syngeneic group was significantly prolonged compared to the acute and chronic KO rejection groups (***P < 0.001), and the grafts in the chronic rejection groups showed significantly delayed rejection responses compared to the acute rejection group (chronic KO; **P < 0.01, chronic BM12; **P < 0.001). In addition, the chronic BM12 group showed significant rejection delay compared to the chronic KO group. Pooled data from 3 independent experiments. Syngeneic; n = 5, acute; n = 10, chronic KO; n = 7, and chronic BM12; n = 9., ****P < 0.0001 by Log-rank test with GraphPad Prism.
