Fig. 9
From: Chronic rejection models for vascularized composite tissue allotransplantation
Chronic rejection features following VCA under conventional immunosuppression. A, Representative gross findings 2 weeks and 6 weeks after chronic KO and BM12 VCA respectively. B, H&E-stained images of skin and vessels from chronic rejection models after using low-dose of tacrolimus. Scale bar; 20 µm, arrows; mast cell. C, Histopathological scores of the transplanted grafts. Stacked column graph of adnexal atrophy, dermal fibrosis, and mast cell counts in the dermis, respectively (0; none, 1; minimal, 2; mild, 3; moderate, 4; severe). D, Stacked column graphs of intimal arteritis (mononuclear cells underneath arterial endothelium; 0; none, 1; < 25%, 2; > 25%, 3; transmural involvement, intimal thickening (0; none, 1; < 25%, 2; 25–50%, 3; > 50%), and CAV. Data represent one independent experiment, n = 3 per group. Tac; low-dose tacrolimus.
