Fig. 1 | Scientific Reports

Fig. 1

From: Polydatin exerts therapeutic effects on myelodysplastic syndrome by inhibiting the protein expression of oncogenes via hypermethylation in vitro

Fig. 1

The 850 K BeadChip DNA methylation data revealed an aberrant methylation pattern in 17 MDS patients compared with 14 healthy donors. (A) Heatmap of the top 1000 DMSs ranked by differential values, comparing MDS patients to healthy donors. (B) Volcano plot of the DMSs between MDS patients and healthy donors. Red (up) represents the hypermethylated sites, and blue (down) represents the hypomethylated genes. (C) KEGG pathway enrichment analysis of differentially hypomethylated genes in MDS patients compared with healthy donors. (D) PPI network analysis of differentially hypomethylated genes in MDS patients; the size and intensity of the nodes correspond to the degree of interaction, with larger and darker nodes indicating higher degree values.

Back to article page