Fig. 6 | Scientific Reports

Fig. 6

From: Huaxian formula alleviates nickel oxide nanoparticle-induced pulmonary fibrosis via PI3K/AKT signaling

Fig. 6

The 3D and 2D docking patterns and interactions of HXF with the targets in the PI3K/AKT signaling pathway. (A-J) The molecular docking quercetin with PI3K, quercetin with AKT, luteolin with PI3K, luteolin with AKT, kaempferol with PI3K, kaempferol with AKT, beta-sitosterol with PI3K, isorhamnetin with PI3K, isorhamnetin with AKT, and formononetin with AKT, respectively. The protein backbone is represented in light blue, amino acid residues interacting with ligands in pale green, and the drug molecules in light magenta. Yellow dashed lines indicate the distances between HXF components and amino acid residues in these 3D structures. This figure was generated using AutoDock Vina (v1.5.7, https://autodock.scripps.edu/), LigPlot+ (v2.2.9, https://www.ebi.ac.uk/), PyMOL (v3.0.4, https://pymol.org/), and GraphPad Prism (v7.0, https://www.graphpad.com/).

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