Fig. 2 | Scientific Reports

Fig. 2

From: Systems serology-based comparison of humoral immune responses induced by liposome or aluminum hydroxide adjuvanted SARS-CoV-2 spike protein

Fig. 2

Univariate analysis of functional antibody responses induced by the adjuvants. (A) A violin plot showing univariate comparisons of SARS-CoV-2 S, S1, S2, and RBD-specific antibody profiling between the groups. Groups received PBS (used as a vehicle control), S protein alone, or S protein formulated with ILA or alum. Mice were immunized twice at two-week intervals, and sera collected on days 14 and 28 post-initial immunization were used for analysis. Measurements are provided as log10 MFI. (B) SARS-CoV-2 S-specific FcγR binding was analyzed in day 14 and 28 samples. (C) ADCP, ADNP, and ADCD in immunized mice groups. Dots represent replicates (n = 10). The dashed line indicates the median value of each distribution. System serology univariate comparison statistical significance between ILA and alum was analyzed via Mann–Whitney U tests. Error bars indicate mean ± SEM. P values: *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.

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