Fig. 2 | Scientific Reports

Fig. 2

From: Small intestinal neuroendocrine tumors lack early genomic drivers, acquire DNA repair defects and harbor hallmarks of low REST expression

Fig. 2

Evolution of siNETs and their mutational processes. (a–d) Scatter plots of the predicted number of mutated alleles that are shared and sample-specific for matched primary and metastasis. (e) Definition of thresholds for predicted number of mutated alleles to determine shared (purple), primary-specific (blue), and metastasis-specific (red) mutations of the major clone. (f, g) Mutational signatures of shared and primary/metastasis-specific mutations. (f) Number of SNVs is indicated above each bar. (g) Tested using Kruskall-Wallis, *: p < 0.05.

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