Fig. 1
From: CLN3 disease disrupts very early postnatal hippocampal maturation
CLN3 disease mice accumulate GPIs, but not other GPDs, by p11 throughout the brain. HILIC method with full scan in negative mode was performed on individual brain regions from Cln3−/− (blue), Cln3−/+ (gray), and Cln3−/+ (black) mice. (A) Gycerophosphoinositol (GPI) (B) glycerophosphoglycerol (GPG), (C) Glycerophosphocholine (GPC), (D) glycerophosphoethanolamine (GPE), and Glycerophosphoserine (GPS). Data are mean ± s.e.m. (n = 6 mice per genotype; 3 female, 3 male). 2-Way ANOVA with multiple comparisons was performed between all genotypes within a brain region and between the same genotypes between different brain regions (p values; *< 0.05, ** <0.01, *** < 0.0005, **** <0.0001).
