Fig. 10

Construction of a prognostic risk model based on MEX3 family co-expression genes in HCC in the TCGA cohort. (A) Coefficients of the selected features across different lambda values. (B) Partial likelihood deviance plotted against log(λ) using the LASSO Cox regression model. (C) The correlations were observed between these 17 genes in HCC. (***p < 0.001). (D) Risk score analysis of the 17 prognostic risk MEX3 family co-expression genes prognostic signature. The top panel shows patients stratified into high- (red) and low-risk (blue) groups based on the median risk score. The middle panel illustrates the survival status of HCC patients, with blue dots indicating survivors and red dots representing deceased patients. The bottom panel presents the expression profiles of the 17 genes, with blue and red denoting low- and high-risk groups, respectively. (E) Kaplan–Meier survival curves comparing overall survival between high- and low-risk groups. (F) Time-dependent ROC curves evaluating the predictive accuracy of the risk score.