Scientific Reports

Table 7 Covariate-adjusted comparison of treatment effects of medication and DBS: medication change (“med on” – “med off”) and DBS programming change (“DBS on” – “DBS off”).

From: Medication versus globus pallidus internus deep brain stimulation in Parkinson’s disease with deep learning video analysis of finger tapping

		p Value
Amplitude	Median^a ↑	0.29
	IQR^b ↓	0.16
	Minimum^b ↑	0.02
	Maximum^a ↑	0.86
	Entropy^a ↓	0.02
Speed	Median^a ↑	0.39
	IQR^a ↑	0.002*
	Minimum^b ↔	0.11
	Maximum^b ↑	0.51
Acceleration	Median^b ↔	0.63
	IQR^b ↑	0.005
	Minimum^b ↓	0.56
	Maximum^b ↑	0.38
Aperiodicity^a ↓		0.09
Period	Median^b ↓	\(\:<\)0.001*
	IQR^b ↓	0.03
	Minimum^b ↓	\(\:<\)0.001*
	Maximum^b ↓	\(\:<\)0.001*
	Entropy^b ↓	0.05
Fatigue^b (set n = 78)^c ↓		0.06
Freeze^b (set n = 56)^c ↓		0.63

DBS, deep brain stimulation. IQR, interquartile range.
^a Parametric variables.
^bNonparametric variables converted to ranks for analysis.
^cComputed using 78 video sets for fatigue and 56 for freeze parameter.
* Significant p values. P values < 0.05/21.

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