Fig. 7 | Scientific Reports

Fig. 7

From: Targeted pancreatic cancer therapy using 4-farnesyloxycoumarin conjugated nanocrystalline cellulose and Chitosan nanoparticles

Fig. 7

Real-time PCR assay for mRNA expression of caspase 3, SOD, p21, and p53 in PANC-1 cells treated with 4-FOC-conjugated NCC/CTAB/CS NPs. At 61 µg/mL, caspase 3 expression (A) increased to 2.25 ± 0.33, indicating apoptosis involvement, while SOD (B) and p21 (C) upregulated, reflecting responses to oxidative stress and cell cycle regulation. p53 levels (D) elevated significantly at both 61 µg/mL (2.71 ± 0.29) and 81 µg/mL (2.15 ± 0.26), underscoring its role in the cellular stress response. These results suggest that 4-FOC-conjugated NCC/CTAB/CS NPs can modulate key gene expressions related to apoptosis and cell cycle regulation in a concentration-dependent manner. The data is presented as mean ± standard deviation (SD), and statistical significance is denoted as *P < 0.05.

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