Fig. 3

(A) Quantification of total HexCer in GBA1^{L444P/L444P(I)}α fibroblasts treated with vehicle or CBE (mean ± SD normalized on ctrl, n = 3). Unpaired t test, *** p 0.0007. (B) GBA1^{L444P/L444P(I)}α fibroblasts treated for 10 days with the indicated amount of GT-02216 (mean ± SD normalized on vehicle, n = 3). Ordinary 1way ANOVA (p < .0001) and Dunnett’s multiple tests against vehicle. ** p < .01, *** p < .001, **** p < .0001. (C) Quantification of total HexCer in GBA1^{L444P/L444P(I)}α compared to GBA1^WT(XX) fibroblasts (mean ± SD normalized on GBA1^WT(XX), n = 3). Unpaired t test, *** p 0.0006. (D) As in B. for GBA1^WT(XX) fibroblasts. Ordinary 1way ANOVA (p 0.0002) and Dunnett’s multiple tests against vehicle. ** p < .01, *** p < .001, **** p < .0001.