Fig. 12
From: Unraveling the role of HIF2α in melanoma progression and epithelial–mesenchymal transition
Effects of Hypoxia and HIF-2α Knockdown on HIF-2α, E-cadherin, N-cadherin, and Vimentin mRNA Expression in A375 Cells. (A) Hypoxia significantly increased the mRNA levels of HIF-2α in A375 cells (*P < 0.01); In the NC group, no significant changes in mRNA expression were observed under hypoxic conditions. HIF-2α knockdown under hypoxia led to a significant reduction in the mRNA levels of HIF-2αcompared to the NC group(#P < 0.01). (B) Hypoxia induced a modest yet statistically significant reduction in the mRNA levels of E-cadherin in A375 cells (*P < 0.01);In the NC group, no significant changes in mRNA expression were observed under hypoxic conditions.HIF-2α knockdown under hypoxia led to a modest but statistically significant upregulation of E-cadherin mRNA levels, as compared to the NC group(#P < 0.01). (C,D) Hypoxia induced a modest yet statistically significant upregulation in the mRNA levels of N-cadherin and Vimentin in A375 cells (*P < 0.01); In the NC group, no significant changes in mRNA expression were observed under hypoxic conditions.HIF-2α knockdown under hypoxia led to a modest but statistically significant reduction of N-cadherin and Vimentin mRNA levels, as compared to the NC group (#P < 0.01).
