Fig. 2
Effect of BaNPs in combination with CT-based or conventional RT. (a) shows the in-vitro results. CT irradiation with a 1.3 Gy exposure effectively reduces the colony forming ability of murine H8N8 breast tumor cells, but the BaNPs do not show an additional effect. 1.1 Gy exposure using the RS225 leads to a significant decrease of the colony forming ability of the tumor cells co-cultured with the BaNPs compared to irradiated cells only as well as to the controls. (b) shows the in-vivo results as relative tumor sizes (tumor size at the end of the experiment normalized to the size at the beginning of the treatment). A similar trend to the in-vitro results is found, where CT irradiation with a total dose of 26 Gy resulted in a strongly reduced tumor growth without an additional effect of the BaNPs. Irradiation with RS225 and a dose of 11 Gy resulted in a significant difference between tumors with and without injected BaNPs. c) development of the body weight in the individual experimental groups normalized to the start of the treatment (day 0). A moderate weight loss in all irradiated groups of maximally 5% was observed. (ns = not significant, * = p<0.05, ** = p<0.01, *** = p<1e-3, **** = p<1e-4).
