Table 1 Results of integrating multi-omics evidence.
Expo ID | Outco gene | p SMR | p SMR multi | p HEIDI | OR SMR (95% CI) |
|---|---|---|---|---|---|
cg15699386(mQTL) | MUC1(eQTL) | 2.87E−07 | 2.87E−07 | 2.20E−05 | 0.76 (0.68–0.84) |
cg03321503(mQTL) | MAP3K7(eQTL) | 8.27E−36 | 6.84E−33 | 6.02E−07 | 1.24 (1.2–1.28) |
cg23697202(mQTL) | MAP3K7(eQTL) | 1.27E−14 | 3.61E−15 | 0.021594 | 1.58 (1.41–1.78) |
cg17562697(mQTL) | MAP3K7(eQTL) | 1.22E−50 | 1.37E−42 | 2.74E−11 | 0.88 (0.86–0.89) |
cg18814314(mQTL) | HSF1(eQTL) | 4.40E−11 | 2.66E−10 | 0.045205 | 0.92 (0.89–0.94) |
cg18779092(mQTL) | NDUFA9(eQTL) | 1.56E−09 | 1.56E−09 | 0.132647 | 0.5 (0.4–0.63) |
cg03680150(mQTL) | NDUFA9(eQTL) | 1.09E−15 | 1.09E−15 | 0.247113 | 1.59 (1.42–1.78) |
cg25251738(mQTL) | HMGB1(eQTL) | 5.05E−10 | 5.05E−10 | 0.019692 | 1.19 (1.13–1.26) |
cg09792463(mQTL) | FOXO1(eQTL) | 4.84E−06 | 4.84E−06 | 0.009601 | 0.9 (0.86–0.94) |
cg23413567(mQTL) | FOXO1(eQTL) | 1.34E−05 | 1.34E−05 | 0.655891 | 0.75 (0.66–0.86) |
cg10696351(mQTL) | FOXO1(eQTL) | 9.47E−08 | 3.12E−07 | 0.004635 | 0.92 (0.89–0.95) |
cg11244402(mQTL) | FOXO1(eQTL) | 3.66E−07 | 3.66E−07 | 0.079158 | 0.86 (0.82–0.91) |
cg26155983(mQTL) | GPX2(eQTL) | 2.84E−06 | 2.84E−06 | 0.001973 | 1.27 (1.15–1.4) |
cg17243289(mQTL) | SMAD2(eQTL) | 3.50E−14 | 2.84E−12 | 0.001039 | 1.18 (1.13–1.23) |
FOXO1(eQTL) | Forkhead box protein O1(pQTL) | 0.054 | 0.011 | 0.027 | 0.83 (0.68–1) |
