Fig. 1 | Scientific Reports

Fig. 1

From: 2-Methoxyestradiol attenuates lung injury induced by chronic intermittent hypoxia via inhibiting the HIF1-α/SLC7A11 pathway

Fig. 1

CIH-induced lung tissue injury and ferroptosis-related gene expression changes (n = 6). (A) HE staining. Blue arrows indicate lymphocytes, red arrows indicate neutrophils; (B), Lung injury score; (C), Masson staining; (D), The proportion of collagen areas in lung tissue. (E), CIH upregulated HIF-1α mRNA while downregulating SLC7A11 and GPX4 mRNA compared with the control group; (F), CIH upregulated HIF-1α protein and reduced SLC7A11 and GPX4 protein levels compared with the control group. Data are shown as the mean ± SD. * p < 0. 05; *** p < 0. 001; **** p < 0. 0001.

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