Fig. 6 | Scientific Reports

Fig. 6

From: Synthesis, anticancer evaluation, and electrochemical investigation of new chiral pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides

Fig. 6

Reactive oxygen species (ROS) generation in HT-29 (A) and PC-3 (B) cells after 2-h treatment with MM124 and MM125 at concentrations of 0.5xIC50, IC50, and 2xIC50 concentrations and 500 μM H2O2 used in the experiment as a positive control. Data were presented as median relative fluorescence intensity units (RFU) with interquartile range and minimal and maximal values. The Kruskal–Wallis test was employed to show a statistically significant difference between groups. Dunn’s multiple comparisons test was used to compare mean rank differences between control and treated groups. In all groups, N = 15. Significant changes: * p < 0.05; ** p < 0.01, ***; p < 0.001; p < 0.0001.

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