Table 5 Predicted ADMET properties of MM124 and MM125.

From: Synthesis, anticancer evaluation, and electrochemical investigation of new chiral pyrazolo[4,3-e]tetrazolo[1,5-b][1,2,4]triazine sulfonamides

Compound /Property

Gastrointestinal (GI) absorption

CYP2D6 inhibitor

CYP3A4 inhibitor

Blood Brain Barrier (BBB)

permeability

P-glycoprotein substrate

Ames Toxicity

Cardiotoxicity

(hERG inhibition)

Hepatotoxicity

MM124

Low

No

No

No

Yes

No

Ambiguous

Yes

MM125

Low

No

No/Yes

No

Yes

No

Ambiguous

Yes

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