Table 2 Prescribing measures used in the analysis. Source and calculation from subsets.

From: Using OpenPrescribing.net to evaluate neighbourhood-level prescribing of inhalers for asthma and COPD

Measure

Definition

Subsets for Calculation

Rationale

Reading

Source

environmental inhalers (Environmental measure).

MDIs dispensed as a % of all MDIs/DPIs dispensed.

(mdi/mdi_dpi) * 100

The NHS has committed to reducing its carbon footprint by 51% by 2025. DPIs emit less harmful greenhouse gas than traditional MDIs and the NHS long term plan supports the use of these inhalers where clinically appropriate.

Higher = ‘worse’.

10

ics laba lama combo pppm (’Severe’ asthma/COPD prescribing).

Number ICS/LABA/LAMA triple therapy inhaler prescriptions dispensed per asthma/COPD patient per month.

ics_laba_lama_combo/patients_resp_lsoa

ICS triple therapy is prescribed as regular maintenance for severe asthma and COPD. A relatively higher value between neighbourhoods would indicate greater prevalence of severe conditions compared to other severity levels.

Higher = ‘worse’.

6

ics laba pppm (’Moderate-Severe’ asthma/COPD prescribing).

Number ICS/LABA combination inhaler prescriptions dispensed per asthma/COPD patient per month.

ics_laba/patients_resp_lsoa

ICS/LABA combination inhalers are first line therapy for asthma, but only for COPD patients with high exacerbation risk. A relatively higher value between neighbourhoods would indicate greater prevalence of moderate-to-severe asthma cases compared to other severity levels.

Higher = ‘worse’.

6

ics pppm (’Mild-Moderate’ asthma prescribing).

Number ICS monotherapy inhaler prescriptions dispensed per asthma/COPD patient per month.

ics_mono/patients_resp_lsoa

ICS monotherapy inhalers are prescribed for mild-moderate asthma, but not recommended for COPD patients without asthma. A relatively higher value between neighbourhoods would indicate greater prevalence of mild-moderate asthma cases compared to other severity levels.

Lower = ‘worse’.

6

ics dose (High dose ICS).

Number ‘high dose’ ICS prescriptions dispensed as a % of all ICS-containing prescriptions.

(high_dose_ics_products/all_ics_products) * 100

Greater potential risk of systemic side effects with high-dose ICS products.

Higher = ‘worse’.

6,7

laba ics (LABA/LAMA to ICS-containing prescriptions ratio).

Number of LABA/LAMA mono/combination inhaler prescriptions dispensed for each ICS-containing prescription.

laba_lama/all_ics_products

LABA/LAMA monotherapies are never recommended as sole treatment for asthma, but are first-line treatments for COPD. A higher value in this measure could therefore indicate inappropriate prescribing for asthma, or treatment optimisation for COPD.

Higher = ‘worse’ (asthma)/Higher = ‘better’ (COPD).

GP advisor.

saba (Excess SABA prescribing).

SABA inhalers dispensed as a % of ICS and SABA inhalers.

(saba_inhaler_products/all_saba_ics_products) * 100

High use of SABA and poor adherence in the use of ICS in asthma suggests poor control. These patients should be reviewed regularly to ensure good control.

Higher = ‘worse’.

8

  1. COPD chronic obstructive pulmonary disease, DPI dry powder inhaler, GP general practice, ICS inhaled corticosteroids, LABA long-acting beta agonist, LAMA long-acting muscarinic antagonists, MDI metered-dose inhaler, SABA short-acting beta agonist.