Fig. 4 | Scientific Reports

Fig. 4

From: Elucidating the tumor microenvironment interactions in breast, cervical, and ovarian cancer through single-cell RNA sequencing

Fig. 4

Identification and classification of malignant fibroblast subtypes in different cancer types. (A). The tSNE plots shows two distinct subtypes of fibroblasts in BC, labeled as BC-iCAF (CXCL14) and BC-myCAF (MYH11). (B) The tSNE plots shows two subtypes of fibroblasts are identified in CC, namely CC-iCAF (CXCL14) and CC-myCAF (RGS5). (C) In OC, three fibroblast subtypes are identified, which are OC-proCAF (C7), OC-myCAF (MYH11), and OC-matCAF (POSTN). (D) The cell composition plot demonstrates a high abundance of matCAF in late-stage OC samples, indicating its association with advanced tumor development and progression.

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