Fig. 8

Cell-to-cell interaction analysis between CAFs and macrophage subtypes in the tumor microenvironment using “CellChat”. (A) The CellChat analysis for BC samples shows that iCAF and Macro_CHIT1 + subtypes exhibit the highest level of communication among the cell subtypes within the tumor microenvironment. (B) In CC samples, the iCAF and Macro_FCER1A + subtypes are identified as having the most active cell-to-cell interactions. (C) In OC, matCAF and Macro_FCN1 + subtypes demonstrate the most significant cell-to-cell interactions.