Fig. 2
From: Taurine as a supplement for treating type II diabetes mellitus with metformin and DPP4 inhibitor
Metabolomic changes associated with drug treatments. (a) KEGG pathway enrichment analysis of plasma in T2DM-DHA patients treated with metformin as compared to that without the treatment. Metformin treatment resulted in upregulating pyruvate metabolism as well as glycine, serine and threonine metabolism. (b) KEGG pathway enrichment analysis of plasma in T2DM-DHA patients under insulin treatment as compared to that without the treatment. The treatment perturbed the metabolisms of fatty acids and unbranched amino acids. (c) KEGG pathway enrichment analysis of plasma in T2DM-DHA patients treated with both metformin and DPP4 inhibitor as compared to that without the treatment. The combined treatment altered more metabolic pathways, as compared to use metformin alone and down-regulated several metabolic pathways that were up-regulated in T2DM-DHA.
