Table 1 Clinical characteristics of the study groups.
From: Altered levels of angiogenin and tRNA-derived fragments associate with severe asthma
Screening cohort | Healthy subjets n = 13 | Patients with mild asthma n = 14 | Patients with severe asthma n = 13 |
|---|---|---|---|
Demographic characteristics | |||
Age, median (min–max) | 41 (27–64) | 55 (24–68) | 51 (26–76) |
Sex (M/F) | 7/6 | 6/8 | 6/7 |
IMC (Kg/m2) mean ± SD | 25.0 ± 3.13 | 31.6 ± 6.91 | 30.7 ± 7.66 |
Spirometry | |||
FEV1 (mL); median (min–max) | – | 72.0 (46–96) | 59.5 (24—85) |
FEV1/FVC ratio; median (min–max) | – | 88.0 (58.0—108) | 82.5 (61.0–100) |
Reversibility (%); median (min–max) | – | 8.30 (-0.67–26.0) | 7.80 (-3.90–25.8) |
Blood leukocyte formula | |||
Lymphocyte (%); median (min–max) | 33.0 (26–46) | 27.5 (16–38) | 32.0 (19–47) |
Monocyte (%); median (min–max) | 6 (3–10) | 5.1 (3–9) | 6.50 (3.3–13) |
Neutrophils (%); median (min–max) | 63.0 (40–66) | 63.1 (51–79) | 56.5 (47–65) |
Eosinophils (%); median (min–max) | 2 (1–4) | 3.9 (2.4–16) | 3.3 (2–7.2) |
IgE; median (min–max) | 139 (1.5–310) | 172 (34–3050) | 125 (29–1243) |
Sputum characteristics | |||
Eosinophilic/neutrophilic/paucigranulocytic | 2/6/5/0 | 5/4/3/2 | 8/2/0/3 |
Macrophages (%); median (min–max) | 21.6 (5.8–40) | 24 (6–57) | 17.5 (7.7–34.3) |
Neutrophils (%); median (min–max) | 75.0 (54–93) | 71.3 (36–93) | 71.0 (56–89) |
Eosinophils (%); median (min–max) | 2.00 (0–8) | 3.0 (0.5–6) | 4.30 (1.6–29)(***) |
