Fig. 4
Expression of TIMM8A in breast cancer. (A) Expression of TIMM8A in breast cancer cell lines from the CCLE dataset. (B) Differential expression of TIMM8A breast cancer primary site cell lines and breast cancer metastatic site cell lines. (C) Differential expression of TIMM8A in cancerous and paraneoplastic tissues in breast cancer. (D–F) Expression of TIMM8A in mammary epithelial cell lines and several breast cancer cell lines analyzed by qRT-PCR and Western blot, (G) Kaplan–Meier analysis of the effect of TIMM8A on overall survival in luminal A subtype breast cancer based on the METABRIC database, (H) Kaplan–Meier analysis of the effect of TIMM8A on overall survival in claudin-low subtype breast cancer based on the METABRIC database. The results shown are representative of at least three independent experiments. qRT-PCR, quantitative real-time PCR. The student’s t-test or one-way ANOVA was used to detect the differences among groups. *P < 0.05; **P < 0.01; ***P < 0.001. Samples were derived from the same experiment and gels/blots were processed in parallel. Original blots/gels are presented in the Supplementary File.
