Table 2 IC50 and efficacy of TOP2-targeting drugs with or without ICRF193.

From: ICRF193 potentiates the genotoxicity of etoposide

 

Without ICRF193

With ICRF193

IC50 [nM]

Efficacy [% inhibition]

IC50 [nM]

Efficacy [% inhibition]

Aclarubicin

12.36 ± 2.23

86.82 ± 0.67

15.49 ± 1.98

83.01 ± 0.94

Idarubicin

105.83 ± 59.96

83.75 ± 0.48

199.42 ± 58.73

84.81 ± 0.29

Daunorubicin

31.49 ± 8.9

90.34 ± 1.3

47.07 ± 5.41

89.74 ± 1.13

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