Table 3 IC50 values of etoposide co-treated with/without ICRF193 in DNA synthesis assay.

From: ICRF193 potentiates the genotoxicity of etoposide

ICRF193 concentrations [nM]

IC50 values of etoposide [µM]

Fold change

955

15.5 ± 8.4

1.09

477

7.9 ± 1.1*

2.14

239

6.7 ± 0.5*

2.53

119

9.14 ± 4.0

1.84

59.7

8.6 ± 1.6

1.96

29.8

12.3 ± 4.6

1.37

0

16.9 ± 5.4

 
  1. The fold change was calculated based on the IC50 value of etoposide without ICRF193. *p-value < 0.05.
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