Fig. 5

Novel mutations present in ORF1ab genes were mapped onto 2-D and 3-D protein models: (A) nsp1, (B) nsp2, (C) nsp3, (D) nsp4, (E) nsp5/3 CLpro, (F) nsp6, (G) RdRp, (H) nsp15, and (I) nsp16. Structures were rendered using UCSF Chimera and RCSB PDB numbers were provided58. Individual protein domains were indicated in blue and multimers/other molecules were indicated as gray. Mutations were highlighted and noted in red.