Table 2 Functional analysis of whole proteins identified in freshly prepared L. reuteri DSM 17938 pMVs and bMVs. Proteins identified within the UniProtKB L. reuteri repository (296 proteins in number) were subjected to functional enrichment based on KEGG database. Top-14 enriched pathways are reported. Shown is the pathway code, the corresponding description, count in network, strength and false discovery rate (FDR).
KEGG pathways | ||||
|---|---|---|---|---|
Pathway | Description | Count in network | Strength | FDR |
Map00261 | Monobactam biosynthesis | 4 of 4 | 0.94 | 0.0393 |
Map00020 | Citrate cycle (TCA) | 5 of 7 | 0.80 | 0.0388 |
Map00010 | Glycolysis/Gluconeogenesis | 18 of 35 | 0.65 | 4.14e-05 |
Map00030 | Pentose phosphate pathway | 11 of 22 | 0.64 | 0.0030 |
Map01200 | Carbon metabolism | 23 of 52 | 0.59 | 1.50e-05 |
Map00190 | Oxidative phosphorylation | 8 of 18 | 0.59 | 0.0305 |
Map00620 | Pyruvate metabolism | 17 of 40 | 0.57 | 0.00041 |
Map00270 | Cysteine and methionine metabolism | 11 of 28 | 0.54 | 0.0132 |
Map00640 | Propanoate metabolism | 9 of 24 | 0.52 | 0.0388 |
Map01120 | Microbial metabolism in diverse environments | 40 of 111 | 0.50 | 3.36e-07 |
Map01230 | Biosynthesis of amino acids | 24 of 68 | 0.49 | 0.00014 |
Map03010 | Ribosome | 19 of 59 | 0.45 | 0.0026 |
Map01110 | Biosynthesis of secondary metabolites | 57 of 234 | 0.33 | 7.10e-06 |
Map01100 | Metabolic pathways | 116 of 617 | 0.22 | 3.36e-07 |
