Table 3 Pathophysiological alterations observed in liver cirrhosis.

From: A PBPK modeling approach for personalized dose optimization of nicardipine in renal and hepatic dysfunction

Variables

Control

PK-Sim default

CP-A

Functional liver volumea

1

2.2

0.81

Hematocrit (%)a

40.9

0.47

36.6

Plasma protein factorb

1

0.81

GFR (mL/min)a

120

21.5

83.7

Blood flow (mL/min)b

 Liver

18.83

1.3

 Kidney

228.58

0.88

 Bone and other organs

1.75

  1. aReference values extracted from29, bReference values extracted from28.