Table 4 Correlations of cortical ASL parameters with WMH volumes (Cohen’s f2 > 0.15).

From: Microstructural and microvascular features of white matter hyperintensities and their association with small vessel disease markers

Parameter

Cohen’s f2

Dependence on WMH vol

Network

Anatomic Region (MNI coord.)

PS

0.29

negative

DMN

Left Lateral Parietal (-39,-77,33)

0.18

negative

SMN

Right Lateral (56,-10,29)

0.20

negative

VIS

Left Lateral (-37,-79,10)

0.16

negative

SAL

ACC (0,22,35)

0.52

negative

SAL

Left Anterior Insula (-44,13,1)

0.32

positive

SAL

Right Anterior Insula (47,14,0)

0.23

positive

SAL

Left SMG (-60,-39,31)

0.37

positive

DAN

Left FEF (-27,-9,64)

tex

0.17

positive

DMN

Right Lateral Parietal (47,-67,29)

0.31

positive

SAL

Left RPFC (-32,45,27)

0.26

negative

DAN

Left FEF (-27,-9,64)

0.54

positive

FPN

Left LPFC (-43,33,28)

0.15

positive

LAN

Right pSTG (59,-42,13)

0.16

positive

CER

Anterior (0,-63,-30)

tA

0.31

positive

DMN

PCC (1,-61,38)

0.26

positive

SMN

Left Lateral (-55,-12,29)

0.25

positive

SMN

Right Lateral (56,-10,29)

0.22

positive

VIS

Medial (2,-79,12)

0.43

positive

SAL

ACC (0,22,35)

0.16

positive

SAL

Left Anterior Insula (-44,13,1)

0.35

positive

SAL

Right Anterior Insula (47,14,0)

0.27

positive

SAL

Left RPFC (-32,45,27)

0.41

positive

SAL

Right RPFC (32,46,27)

0.27

positive

SAL

Left SMG (-60,-39,31)

0.63

positive

SAL

Right SMG (62,-35,32)

0.21

negative

DAN

Left FEF (-27,-9,64)

0.17

positive

DAN

Left IPS (-39,-43,52)

0.19

positive

DAN

Right IPS (39,-42,54)

0.52

positive

FPN

Right LPFC (41,38,30)

0.61

positive

FPN

Right PPC (52,-52,45)

R1t

0.51

positive

DMN

MPFC (1,55,-3)

0.21

positive

DMN

Left Lateral Parietal (-39,-77,33)

0.28

positive

SMN

Left Lateral (-55,-12,29)

0.40

positive

SMN

Right Lateral (56,-10,29)

1.18

positive

SMN

Superior (0,-31,67)

0.57

positive

VIS

Lateral (38,-72,13)

0.33

positive

SAL

ACC (0,22,35)

0.64

positive

SAL

Left RPFC (-32,45,27)

0.15

positive

SAL

Left SMG (-60,-39,31)

0.59

positive

SAL

Left SMG (-60,-39,31)

0.88

positive

DAN

Right FEF (30,-6,64)

0.21

positive

DAN

Left IPS (-39,-43,52)

0.21

positive

DAN

Right IPS (39,-42,54)

0.31

positive

FPN

Left LPFC (-43,33,28)

0.29

positive

FPN

Right PPC (52,-52,45)

1.60

positive

LAN

Left IFG (-51,26,2)

0.47

positive

LAN

Left pSTG (-57,-47,15)

0.33

positive

LAN

Right pSTG (59,-42,13)

0.53

positive

CER

Posterior (0,-79,-32)

CBFp

0.37

positive

SAL

Left RPFC (-32,45,27)

0.15

negative

DAN

Left FEF (-27,-9,64)

0.19

positive

DAN

Right FEF (30,-6,64)

  1. ASL = arterial spin labeling, WMH = white matter hyperintensity, PS = BBB permeability/surface area product, tex = arterial transit time, tA = time of arrival, R1t = tissue R1, CBFp = cerebral blood flow factor, DMN = default mode network, SMN = sensorimotor network, VIS = visual network, SAL = salience network, DAN = dorsal attention network, FPN = fronto-parietal network, LAN = language network, CER = cerebellar network, ACC = anterior cingulate cortex, SMG = supramarginal gyrus, FEF = frontal eye field, RPFC = rostral prefrontal cortex, LPFC = lateral prefrontal cortex, pSTG = posterior superior temporal gyrus, PCC = posterior cingulate cortex, IPS = intraparietal sulcus, PPC = posterior parietal cortex, MPFC = medial prefrontal cortex.
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