Fig. 5 | Scientific Reports

Fig. 5

From: A genetically tractable branch of environmental Pedobacter from the phylum Bacteroidota represents a hotspot for natural product discovery

Fig. 5

Proposed biosynthesis of the cryopeptins. The BGC consists of two NRPS genes (crpB, crpC). CrpB contains a condensation starter domain responsible for the attachment of the fatty acid side chain. We propose that CrpA hydroxylates valine as an intermediate step toward dehydrovaline formation. An iterative assembly mode of CrpB could explain the presence of heptapeptidic cryopeptins.

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