Fig. 1 | Scientific Reports

Fig. 1

From: Uncovering candidate Nanog-Helper genes in early mouse embryo differentiation using differential entropy and network inference

Fig. 1

(a) Simplified Gene Regulatory Network (GRN) driving the differentiation of ICM cells to Epi/PrE cells as proposed in previous modelling studies21,22. (b) Leftmost panel: Schematic view of the evolution of the distribution of gene expression of prototype genes. Rightmost panel: Schematic profiles of the evolution of inter-cellular entropy during the differentiation process. We hypothesize that a gene that initiates the coordination of pluripotency markers alongside Nanog (so-called “Helper genes”), displays a similar inter-cellular entropy profile. (c) Number of cells per cellular stage available for each single cell expression data used in this study.

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