Fig. 5
From: Crosstalk of injured podocytes with parietal epithelial cells through Wnt4/β-Catenin signaling
The Wnt4 target gene CD44 is expressed in Pax8-positive FSGS lesions. CD44-positive glomerular area was analyzed using immunohistochemistry (A) and correlated with the numbers of Pax8-positive cells per glomerular cross-section (gcs) using Pearson test, using the mean values of Pax8-positive cells and CD44-positive glomerular areas per glomerulus and including animals from all time points excluding day 7 (B). Representative immuno-double stains showing Pax8-positive cells (grey staining) and CD44-positive cells (red-brown staining) in healthy control rats (C) and 35 days after DT injection in hDTR-transgenic rats (D), while nephrin-positive cells did not express CD44 in controls (E) and 35 days after DT injection in hDTR-transgenic rats (F). **p < 0.01 ***p < 0.001.
