Fig. 2

RRAS2 was associated with immune infiltration of HNSCC. (A) RRAS2 expression was negatively related to various cell scores, especially B cells, CD8 + T cells, NK cells and etc. (B) High expression of RRAS2 was associated with unsatisfactory immune response, especially Type-II IFN response. C; D; E. The correlation between RRAS2 expression and B naive cells, CD8 + T cells and T cells follicular helper. F. High expression of RRAS2 meant increased tumor mutation burden (TMB), suggesting that RRAS2 might induced the immunotherapy resistance of HNSCC.