Fig. 4 | Scientific Reports

Fig. 4

From: H3 lysine 18 lactylation-mediated RRAS2 facilitates migration and invasion of head and neck squamous cell carcinoma

Fig. 4

Inhibition of RRAS2 weakened HNSCC cell migration and invasion abilities. A; B. The efficiency of siRNA targeting to RRAS2 was identified by Q-PCR and western blotting. The WB images were cropped, and the original images were presented. C. Inhibition of RRAS2 had no effect on SCC25 and HN12 cell proliferation. D; E. Knockdown of RRAS2 inhibited HN12 and SCC15 migration. F; G. Knockdown of RRAS2 inhibited HN12 and SCC15 invasion. H; I. Scratch healing assay suggested that inhibition of RRAS2 weakened HNSCC cells invasion. J; K. Knockdown of RRAS2 downregulated N-cad and Vimentin, while upregulated E-cad expression.

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