Table 1 Baseline characteristics of 38 patients diagnosed as having NSIP/OP overlap.
Number of patients | 38 |
|---|---|
Age (years) | 59 (49–66) |
Sex (male:female) | 14:24 |
Never smoker | 15 (39.5%) |
BMI | 24.5 ± 4.29 |
Diagnosis | |
ILD associated with anti-ARS antibody-positive | 12 (31.6%) |
IIPs | 11 (29.0%) |
PM/DM | 8 (21.1%) |
Systemic sclerosis | 5 (13.2%) |
MCTD | 1 (2.63%) |
Familial history of IP | 4 (10.5%) |
Symptom | |
Dyspnea | 30 (79.0%) |
Cough | 22 (57.9%) |
Skin rash | 17 (44.7%) |
Weight loss | 6 (15.8%) |
Fever | 6 (15.8%) |
Sputum | 5 (13.2%) |
Pulmonary function test | |
TLC, % pred | 82.5 ± 15.4 |
FVC, % pred | 79.6 ± 17.1 |
FEV1, % pred | 77.1 ± 19.3 |
DLCO, % pred | 68.4 ± 15.6 |
Blood test | |
LDH (U/L) | 229.5 (209.3–295.5) |
KL-6 (U/mL) | 1414.5 (986–2439.5) |
CRP (mg/dL) | 0.28 (0.11–0.76) |
ESR (mm/h) | 26.5 (19.8–42.3) |
pO2 (mmHg) | 78.5 (73.7–83.8) |
Initial treatment | |
Pulse steroid therapy | 20 (52.6%) |
OCS + immunosuppressive | 8 (21.1%) |
OCS | 3 (8.11%) |
Anti-fibrotic therapy | 2 (5.26%) |
Observation | 5 (13.2%) |
Follow-up period (days) | 1399 ± 694 |
