Fig. 3 | Scientific Reports

Fig. 3

From: Dynamic changes in BDNF, VEGF, and GDNF after transplanting human protein-based scaffolds with Wharton’s Jelly MSCs in a rat brain injury model

Fig. 3

MRI images of rat brains after focal injury and transplantation of WJ-MSCs cultured under 5% O2 and suspended in saline (2D) or PL/FB scaffolds. In the striatum, damaged areas (red arrows) and transplanted WJ-MSCs labelled with iron oxide nanoparticles (yellow arrows indicating a black signal) are visible (a). The picture of injured hemisphere shows a decrease in volume (b). Volume measurements were taken at following time points: 24 h, 7, 14 and 21 days post-transplantation (c). Data are presented as a mean ± SD. Statistical analysis was performed using One Way ANOVA followed by Tukey’s multiple comparisons test and compared to the lesion size after ouabain injection without cell/sham transplantation (n = 3, area calculated from three animals; **p < 0.01; ***p < 0.001; ****p < 0.0001; + p < 0.05), with "+" denoting statistical significance between transplantation in saline versus PL and FB scaffolds.

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